Volume 27, Number 3—March 2021
Research
Oral Human Papillomavirus Infection in Children during the First 6 Years of Life, Finland
Stina Syrjänen
, Marjut Rintala, Marja Sarkola, Jaana Willberg, Jaana Rautava, Hanna Koskimaa, Anna Paaso, Kari Syrjänen, Seija Grénman1, and Karolina Louvanto1
, Marjut Rintala, Marja Sarkola, Jaana Willberg, Jaana Rautava, Hanna Koskimaa, Anna Paaso, Kari Syrjänen, Seija Grénman1, and Karolina Louvanto1
Table 1
Prevalence and genotype variation of oral HPV infections among 324 children from birth to 6 y of age*
| Variable | At birth | 3 d | 1 mo | 2 mo | 6 mo | 12 mo | 24 mo | 36 mo | 6 y |
|---|---|---|---|---|---|---|---|---|---|
| Oral sample | 324 | 309 | 300 | 296 | 295 | 291 | 264 | 265 | 201 |
| Mean ± SD age, mo |
0 |
0.08 ± 0.37 |
1.14 ± 0.18 |
2.23 ± 0.33 |
6.41 ± 0.45 |
12.61 ± 0.67 |
24.90 ± 1.01 |
36.98 ± 1.31 |
77.47 ± 11.01 |
| Any HPV+ | 74 (22.8) | 41 (13.3) | 57 (19) | 48 (16.2) | 44 (14.9) | 34 (11.7) | 25 (9.5) | 23 (8.7) | 41 (20.4) |
| Girls, any HPV+ | 35 (47.9) | 19 (46.3) | 25 (43.9) | 29 (60.4) | 20 (46.5) | 20 (58.5) | 14 (56.0) | 10 (43.5) | 20 (49.9) |
| Boys, any HPV+ | 39 (52.1) | 22 (53.7) | 32 (56.1) | 19 (39.6) | 24 (53.5) | 14 (51.5) | 9 (44.0) | 13 (56.5) | 21 (51.2) |
| Single HPV+ | 62 (19.1) | 36 (11.7) | 55 (18.3) | 44 (14.8) | 36 (12.2) | 33 (11.0) | 20(7.6) | 21 (7.9) | 35 (17.4) |
| Multiple HPV (>2) |
12 (3.7) |
5 (1.6) |
2 (0.7) |
4 (1.4) |
8 (2.7) |
1 (0.3) |
4 (1.5) |
2 (0.8) |
6 (3.0) |
| No. HPV genotypes |
15 |
5 |
8 |
7 |
9 |
10 |
7 |
4 |
8 |
| Low-risk HPV | |||||||||
| HPV6 | 11 (3.4) | 5 (1.6) | 3 (1.0) | 7 (2.4) | 4 (1.4) | 3 (1.0) | 1 (0.4) | 2 (0.8) | 4(2.0) |
| HPV11 | 1(0.3) | – | 1 (1.0) | 5 (1.7) | 4 (1.4) | 1 (0.3) | – | 1 (0.4) | – |
| HPV70 |
2 (0.6) |
– |
– |
1 (0.3) |
1 (0.3) |
1 (0.3) |
2 (0.8) |
– |
– |
| High-risk HPV | |||||||||
| HPV16 | 25 (7.7) | 28 (9.1) | 30 (10) | 16 (5.4) | 14 (4.7) | 14 (4.8) | 9 (3.4) | 17 (6.4) | 20(10) |
| HPV18 | 4 (1.2) | 1 (0.3) | 9 (3.0) | 11 (3.7) | 7 (2.4) | 8 (2.7) | 4 (1.5) | 1 (0.4) | 2 (1.0) |
| HPV31 | 31 (0.9) | – | – | 2 (0.7) | – | 1 (0.3) | – | – | 3 (1.5) |
| HPV33 | 2 (0.6) | – | 8 (2.7) | 2 (0.7) | 1 (0.3) | – | 2 (0.8) | – | 2 (1.0) |
| HPV39 | 1 (0.3) | – | 1 (0.3) | – | – | – | – | – | 2 (1.0) |
| HPV45 | 1 (0.3) | – | 1 (0.3) | – | 1 (0.3) | – | – | – | 1 (0.5) |
| HPV51 | – | – | – | – | 1 (0.3) | 1 (0.3) | – | – | – |
| HPV52 | – | – | – | – | – | 1 (0.3) | – | – | – |
| HPV53 | 1 (0.3) | 1 (0.3) | – | – | … | – | – | – | |
| HPV56 | 3 (0.9) | – | – | – | – | 1 (0.3) | 1 (0.4) | – | – |
| HPV58 | 2 (0.6) | – | – | – | – | 1 (0.3) | – | – | 1 (0.5) |
| HPV66 | 4 (1.2) | 1 (0.3) | 2 (0.7) | – | 1 (0.3) | – | 1 (0.4) | – | – |
| HPV68 | 1 (0.3) | – | – | – | – | – | – | – | – |
| HPV82 | 1 (0.3) | – | – | – | – | – | – | – | – |
*Values are no. (%) unless indicated otherwise. Two cases where excluded because of missing sample at birth. HPV, human papillomavirus. –, HPV genotype not found at that visit.
1These senior authors contributed equally to this article.
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