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Volume 23, Number 11—November 2017
Dispatch

Pulmonary versus Nonpulmonary Nontuberculous Mycobacteria, Ontario, Canada

Sarah K. BrodeComments to Author , Alex Marchand-Austin, Frances B. Jamieson, and Theodore K. Marras
Author affiliations: West Park Healthcare Centre, Toronto, Ontario, Canada (S.K. Brode); University of Toronto, Toronto (S.K. Brode, F.B. Jamieson, T.K. Marras); University Health Network and Sinai Health System, Toronto (S.K. Brode, T.K. Marras); Public Health Ontario, Toronto (A. Marchand-Austin, F.B. Jamieson)

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Figure 1

Prevalence of pulmonary and nonpulmonary nontuberculous mycobacteria (NTM) isolation and pulmonary NTM disease in Ontario, Canada, 1998–2010. Annual increase and modeled annual change were 6.3% (3,4) and 1.04 (95% CI 0.696–1.38)/100,000 population (p<0.001) for pulmonary isolation and 8.0% (3) and 0.402 (95% CI 0.307–0.497)/100,000 population (p<0.001) for pulmonary disease. Significant increases occurred in Mycobacterium avium complex (annual change 0.291 [95% CI 0.236–0.346]/100,000 popu

Figure 1. Prevalence of pulmonary and nonpulmonary nontuberculous mycobacteria (NTM) isolation and pulmonary NTM disease in Ontario, Canada, 1998–2010. Annual increase and modeled annual change were 6.3% (3,4) and 1.04 (95% CI 0.696–1.38)/100,000 population (p<0.001) for pulmonary isolation and 8.0% (3) and 0.402 (95% CI 0.307–0.497)/100,000 population (p<0.001) for pulmonary disease. Significant increases occurred in Mycobacterium avium complex (annual change 0.291 [95% CI 0.236–0.346]/100,000 population; p<0.001); M. xenopi (annual change 0.059 [95% CI 0.015–0.103]/100,000 population; p = 0.002); and M. abscessus (annual change 0.019 [95% CI 0.015–0.024]/100,000 population; p<0.001). TB (all body sites) isolation decreased by an average of 2.2% annually (6.5 to 4.9/100,000 population) during the study period. TB, tuberculosis.

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References
  1. Marras  TK, Chedore  P, Ying  AM, Jamieson  F. Isolation prevalence of pulmonary non-tuberculous mycobacteria in Ontario, 1997 2003. Thorax. 2007;62:661–6. DOIPubMedGoogle Scholar
  2. Brode  SK, Daley  CL, Marras  TK. The epidemiologic relationship between tuberculosis and non-tuberculous mycobacterial disease: a systematic review. Int J Tuberc Lung Dis. 2014;18:1370–7. DOIPubMedGoogle Scholar
  3. Marras  TK, Mendelson  D, Marchand-Austin  A, May  K, Jamieson  FB. Pulmonary nontuberculous mycobacterial disease, Ontario, Canada, 1998-2010. Emerg Infect Dis. 2013;19:1889–91. DOIPubMedGoogle Scholar
  4. Al Houqani  M, Jamieson  F, Chedore  P, Mehta  M, May  K, Marras  TK. Isolation prevalence of pulmonary nontuberculous mycobacteria in Ontario in 2007. Can Respir J. 2011;18:19–24. DOIPubMedGoogle Scholar
  5. Prevots  DR, Shaw  PA, Strickland  D, Jackson  LA, Raebel  MA, Blosky  MA, et al. Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am J Respir Crit Care Med. 2010;182:970–6. DOIPubMedGoogle Scholar
  6. Andréjak  C, Thomsen  VO, Johansen  IS, Riis  A, Benfield  TL, Duhaut  P, et al. Nontuberculous pulmonary mycobacteriosis in Denmark: incidence and prognostic factors. Am J Respir Crit Care Med. 2010;181:514–21. DOIPubMedGoogle Scholar
  7. Winthrop  KL, McNelley  E, Kendall  B, Marshall-Olson  A, Morris  C, Cassidy  M, et al. Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease. Am J Respir Crit Care Med. 2010;182:977–82. DOIPubMedGoogle Scholar
  8. Marras  TK, Mehta  M, Chedore  P, May  K, Al Houqani  M, Jamieson  F. Nontuberculous mycobacterial lung infections in Ontario, Canada: clinical and microbiological characteristics. Lung. 2010;188:289–99. DOIPubMedGoogle Scholar
  9. Griffith  DEAT, Aksamit  T, Brown-Elliott  BA, Catanzaro  A, Daley  C, Gordin  F, et al.; ATS Mycobacterial Diseases Subcommittee; American Thoracic Society; Infectious Disease Society of America. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175:367–416. DOIPubMedGoogle Scholar
  10. Fowler  CJ, Olivier  KN, Leung  JM, Smith  CC, Huth  AG, Root  H, et al. Abnormal nasal nitric oxide production, ciliary beat frequency, and Toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium. Am J Respir Crit Care Med. 2013;187:1374–81. DOIPubMedGoogle Scholar
  11. Gould  MK, Tang  T, Liu  IL, Lee  J, Zheng  C, Danforth  KN, et al. Recent trends in the identification of incidental pulmonary nodules. Am J Respir Crit Care Med. 2015;192:1208–14. DOIPubMedGoogle Scholar
  12. van Ingen  J, Hoefsloot  W, Dekhuijzen  PN, Boeree  MJ, van Soolingen  D. The changing pattern of clinical Mycobacterium avium isolation in the Netherlands. Int J Tuberc Lung Dis. 2010;14:1176–80.PubMedGoogle Scholar
  13. Chou  MP, Clements  AC, Thomson  RM. A spatial epidemiological analysis of nontuberculous mycobacterial infections in Queensland, Australia. BMC Infect Dis. 2014;14:279. DOIPubMedGoogle Scholar
  14. Adjemian  J, Olivier  KN, Seitz  AE, Falkinham  JO III, Holland  SM, Prevots  DR. Spatial clusters of nontuberculous mycobacterial lung disease in the United States. Am J Respir Crit Care Med. 2012;186:553–8. DOIPubMedGoogle Scholar
  15. Wentworth  AB, Drage  LA, Wengenack  NL, Wilson  JW, Lohse  CM. Increased incidence of cutaneous nontuberculous mycobacterial infection, 1980 to 2009: a population-based study. Mayo Clin Proc. 2013;88:38–45. DOIPubMedGoogle Scholar

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