Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 30, Number 1—January 2024
Research

Disease-Associated Streptococcus pneumoniae Genetic Variation

Shimin Yang1, Jianyu Chen1, Jinjian Fu1, Jiayin Huang, Ting Li, Zhenjiang Yao, and Xiaohua YeComments to Author 
Author affiliations: Guangdong Pharmaceutical University, Guangzhou, China (S. Yang, J. Chen, J. Huang, T. Li, Z. Yao, X. Ye); Liuzhou Maternity and Child Health Care Hospital, Liuzhou, China (J. Fu)

Main Article

Table 1

Association analysis between dominant genotypes and disease status from study of disease-associated Streptococcus pneumoniae genetic variation*

Genotype Infection isolates, no. (%), n = 349 Carriage
Isolates, no. (%), n = 434		 χ2 p value OR (95% CI)
ST
ST271 102 (29.2) 37 (8.5) 56.78 <0.001 4.43 (2.95–6.67)
  ST902 25 (7.2) 69 (15.9) 13.97 <0.001 0.41 (0.25–0.66)
  ST90 13 (3.7) 60 (13.8) 23.34 <0.001 0.24 (0.13–0.45)
  ST320 33 (9.5) 24 (5.5) 4.42 0.036 1.78 (1.03–3.08)
  ST11972 3 (0.9) 24 (5.5) 12.67 <0.001 0.15 (0.04–0.50)
  ST9396
 1 (0.3)
 22 (5.1)
 15.52
 <0.001
 0.05 (0.01–0.40)
Serotype
19F 150 (43.0) 57 (13.1) 88.61 <0.001 4.99 (3.51–7.08)
  6B 53 (15.2) 142 (32.7) 31.80 <0.001 0.37 (0.26–0.53)
  15A 12 (3.4) 48 (11.1) 15.88 <0.001 0.29 (0.15–0.55)
  23F 29 (8.3) 21 (4.8) 3.90 0.056 1.78 (0.96–3.35)
  23A 10 (2.9) 32 (7.4) 7.74 0.005 0.37 (0.18–0.77)
  6A 24 (6.9) 10 (2.3) 9.74 0.002 3.13 (1.48–6.64)
  19A 15 (4.3) 11 (2.5) 1.87 0.171 1.73 (0.78–3.81)
  14
 15 (4.3)
 11 (2.5)
 1.87
 0.171
 1.73 (0.78–3.81)
GPSC
  GPSC1 160 (45.9) 67 (15.4) 88.88 <0.001 4.64 (3.32–6.48)
  GPSC321 32 (9.2) 70 (16.1) 8.27 0.004 0.52 (0.34–0.82)
  GPSC23 15 (4.3) 65 (15.0) 24.05 <0.001 0.25 (0.14–0.45)
  GPSC10 9 (2.6) 28 (6.5) 6.44 0.011 0.38 (0.18–0.81)
  GPSC69 3 (0.9) 31 (7.1) 18.39 <0.001 0.11 (0.04–0.35)
  GPSC152 13 (3.7) 18 (4.2) 0.09 0.763 0.89 (0.44–1.83)
  GPSC852 19 (5.4) 12 (2.8) 3.65 0.056 2.02 (0.98–4.17)

*Boldface indicates statistical significance. GPSC, global pneumococcal sequencing cluster; OR, odds ratio; ST, sequence type.

Main Article

1These authors contributed equally to this article.

Page created: November 24, 2023
Page updated: December 20, 2023
Page reviewed: December 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external