Best-Evidence HIV behavioral interventions include interventions that have been rigorously evaluated and have shown significant effects in eliminating or reducing sex- or drug-related risk behaviors, reducing the rate of new HIV/STD infections, or increasing HIV-protective behaviors. These interventions meet the PRS efficacy criteria for best evidence and are considered to provide the strongest scientific evidence of efficacy.

• Complete List of all Best-Evidence Interventions
• Subset of Best-Evidence Interventions, by Characteristic

KEY: HS=Heterosexual; HIV+=HIV-positive; HCV+= Hepatitis C-positive; HR=High-risk; MSM=Men who have sex with men; DU=Drug users; CSA=Childhood Sexual Abuse; M=Male; F=Female; T=Transgender; W=White; AA=African American; AI=American Indian; H=Hispanic; API=Asian/Pacific Islander; O=Other racial/ethnic group; GLI=group-level intervention; ILI=individual-level intervention; CLI = community-level intervention

• BART
  Risk category: HR Youth
  Sex: 28% M, 72% F
  Race: 100% AA
  Intervention level: GLI
• Be Proud! Be Responsible!
  Risk category: HR Youth
  Sex: 100% M
  Race: 100% AA
  Intervention level: GLI
• Brief Group Counseling
  Risk category: MSM
  Sex: 100% M
  Race: 100% API
  Intervention level: GLI
• CHOICES
  Risk category: HS Adult
  Sex: 100% F
  Race: 54% W, 29% AA, 5% AI, 3% H, 3% API, 6% O
  Intervention level: GLI
• CLEAR (in person)
  Risk category: HIV+, HR Youth, DU
  Sex: 78% M, 22% F
  Race: 42% H, 26% AA, 23% W, 8% O
  Intervention level: ILI
• Communal Effectance-AIDS Prevention
  Risk category: HS Adult
  Sex: 100% F
  Race: 55% AA, 42% W, 3% O
  Intervention level: GLI
• Connect
  Risk category: HS Adult
  Sex: 50% M, 50% F
  Race: 55% AA, 39% H, 6% O
  Intervention level: ILI, GLI
• ¡Cuídate!
  Risk category: HR Youth
  Sex: 45% M, 55% F
  Race: 100% H
  Intervention level: GLI
• EXPLORE
  Risk category: MSM
  Sex: 100% M
  Race: 72% W, 15% H, 7% AA, 6% O
  Intervention level: ILI
• Female- & Culturally-Specific Negotiation
  Risk category: HS Adult, DU
  Sex: 100% F
  Race: 100% AA
  Intervention level: ILI
• Focus on the Future NEW
  Risk category: HS Adult
  Sex: 100% M
  Race: 100% AA
  Intervention level: ILI
• FOY + ImPACT
  Risk category: HR Youth
  Sex: 42% M, 58% F
  Race: 100% AA
  Intervention level: GLI
• Healthy Living Project NEW
  Risk category: HIV+
  Sex: 79% M, 21% F
  Race: 45% AA, 32% W, 15% H, 8% O
  Intervention level: ILI
• Healthy Relationships
  Risk category: HIV+
  Sex: 70% M, 29% F, 1% transgender
  Race: 74% AA, 22% W, 4% O
  Intervention level: GLI
• Health Improvement Project
  Risk category: HS Adult
  Sex: 45% M, 54% F
  Race: 67% W, 21% AA, 12% O
  Intervention level: GLI
• LIFT NEW
  Risk category: HIV+ w/ CSA
  Sex: 47% M, 53% F
  Race: 68% AA, 17% H, 10% W, 5% O
  Intervention level: GLI
• “light”
  Risk category: HS Adult
  Sex: 42% M, 58% F
  Race: 74% AA, 25% H, 1% O
  Intervention level: GLI
• Modelo de Intervención Psicomédica
  Risk categoryy: DU
  Sex: 89% M, 11% F
  Race: 100% H
  Intervention level: ILI
• Personalized Cognitive Risk-Reduction Counseling
  Risk category: MSM
  Sexx: 100% M
  Race: 74% W, 11% H, 6% API, 3% AA, 6% O
  Intervention level: ILI
• Positive Choice: Interactive Video Doctor NEW
  Risk category: HIV+
  Sex: 79% M, 21% F
  Race: 50% AA, 29% W, 13% H, 8%, O
  Intervention level: ILI
• Project FIO (8 session)
  Risk category: HS Adult
  Sex: 100% F
  Race: 73% AA, 17% H, 10% W, 0.3% API
  Intervention level: GLI
• Project S.A.F.E. (Standard Version)
  Risk category: HS Adult
  Sex: 100% F
  Race: 77% H, 23% AA
  Intervention level: ILI, GLI
• Project START
  Risk category: HS Adult
  Sex: 100% Male
  Race: 52% AA, 23% W, 14% H, 12% O
  Intervention level: ILI
• RESPECT
  Brief Counseling (Best Evidence)
  Enhanced Counseling (Promising Evidence)
  Risk category: HS Adult
  Sex: 57% M, 43% F
  Race: 59% AA, 19% H, 16% W, 6% O
  Intervention level: ILI
• RESPECT Brief Counseling + Booster
  Risk category: HS Adult
  Sex: 54% M, 46% F
  Race: 51% AA, 22% W, 18% H, 9% O
  Intervention level: ILI
• Safe in the City NEW
  Risk category: HS Adult
  Sex: 70% M, 30% F
  Race: 46% W, 25% H, 18% AA, 11% O
  Intervention level: ILI
• SHIELD
  Risk category: DU
  Sex: 61% M, 39% F
  Race: 94% AA, 6% O
  Intervention level: GLI
• SiHLE
  Risk category: HR Youth
  Sex: 100% F
  Race: 100% AA
  Intervention level: GLI
• Sisters Saving Sisters
  Risk category: HR Youth
  Sex: 100% F
  Race: 68% AA, 32% H
  Intervention level: GLI
• Sister-to-Sister: Group Skills-buildingg
  Risk category: HS Adult
  Sex: 100% F
  Race: 100% AA
  Intervention level: GLI
• Sister-to-Sister: One-on-one Skills-building
  Risk category: HS Adult
  Sex: 100% F
  Race: 100% AA
  Intervention level: ILI
• STRIVE NEW
  Risk category: HCV+, DU
  Sexx: 76% M, 24% F
  Race: 57% W, 27% H, 7% AA, 10% O
  Intervention level: GLI
• SUMIT Enhanced Peer-led
  Risk category: HIV+, MSM
  Sex: 100% M
  Race: 51% W, 23% AA, 17% H, 1% API, 1% AI, 7% O
  Intervention level: GLI
• VOICES/VOCES
  Risk categoryy: HS Adult
  Sex: 60% M, 40% F
  Race: 62% AA, 38% H
  Intervention level: GLI
• WiLLOW
  Risk category: HIV+, HS Adult
  Sex: 100% F
  Race: 84% AA, 15% W, 1% O
  Intervention level: GLI
• Women’s Co-Op
  Risk category: HS Adult, DU
  Sex: 100% F
  Race: 100% AA
  Intervention level: ILI, GLI
• Women's Health Promotion
  Risk category: HS Adult
  Sex: 100% F
  Race: 100% H
  Intervention level: GLI